Sorry, really can’t help. I know nothing about macOS. Just posting information that may help you troubleshoot if you are still experiencing a problem.
Since Brave does not crash in a new profile, it may be an extension that is causing a problem. If you have extensions installed, try disabling them. You can then turn them back on one by one to see which extension(s), if any, are causing problems.
General troubleshooting for any OS:
Please make sure you are updated to the lastest Brave version (currently 1.42.97) to see if that resolves the issue. You can also try clearing history/cache for all time on the advanced tab at brave://settings/clearBrowserData, close the browser and reopen.
Older topic links for troubleshooting (specific to macOS):
Crash Reports (update post with crash report id):
Related Brave GitHub Issue Report:
Brave crashes consistently when opening “About Brave” #21424
Please post an update. Include any crash report IDs and any error messages you may have in your update.
Hope this helps. Take care.