I just restarted Brave after updating to Version 1.45.127 Chromium: 107.0.5304.110 (Official Build) (64-bit) and immediately got DNS failures. I reverted to 1.45.123, but still had DNS failures on all lookups (entering IP address directly worked). This was only in Brave, other programs continued to work fine.
I tracked the problem down to the “Use Secure DNS” setting, which had been set to Cloudflare. As soon as i changed that to Google everything started to work again. I’ve got it currently set to “with your current service provider”, assuming that will use my computer’s systemd-resolved.service (does it? or does it really use my “service provider” whatever that means?).
The timing of this coinciding with an update might just be coincidental, especially since i still had the problem after downgrading to the version I had been using minutes earlier. Is Cloudflare blocking requests from Brave suddenly?