F5
I searched the extension store for “F5”. There is no extension for using that hotkey. But two extensions having to do with reloading show up. This hints that F5 is universally known as the refresh key.
F5: https://chrome.google.com/webstore/search/f5
F5 works in Windows file explorer, too.
Custom Hotkeys: https://chrome.google.com/webstore/search/custom%20hotkeys
These inject JS into pages in order to work. Yuck.
I created a Shortcut in System Preferences for F5 in Brave. It works. For giggles I did the same for Mail.
[delete]
I tried to create a Shortcut in System Preferences for [delete] in Brave. It doesn’t allow that key.