Description of the issue: YouTube ads aren’t blocked anymore. When I put ad blocking to aggressive it got rid of the video but audio and ad skip button continued working. Would it be useful to see the .HAR file?
go to brave://components/ if you have Brave Ad Block Resources Library - Version: 1.0.53, then you can’t do anything and just wait for the update.
There was an update in uBlock side that broke Brave scriptlets injection, and Brave already dropped the fix but it has to be in the server to be downloaded by the Browser.
Youtube depends on scriptlet injections to stop the ads and crap, but it affects everyone, not just Nightly users, so better wait until you see you have 1.0.54 to report anything wrong with Brave and Youtube.