@robgt It doesn’t mean your profile is corrupted, but it means it’s settings you have in it that is causing the difference. Now when going back to the other profile, it’ll be having to figure out what’s going on. I was going to ask you what your Shield settings are after reading the initial, as it sounds similar to issues I’ve had when I’ve prevented Scripts and/or Fingerprinting.
Extensions can cause all sorts of issues. For example, check out the post at Brave Browser can't load a page properly even if it doesn't use Brave Shield - #3 by Saoiray