But it is quite laborious via the browser, especially since all configurations can easily disappear so the best is to use an extension like uMatrix which will make all manipulations easy, temporary or not, cookies, cache, images, xhr, scripts etc… This is the best extension to date for this.
Other extension like Scriptsafe is also good for this, block webgl, webrtc, fingerprint, spoofer etc
Use uMatrix and uBlock Origin is also possible, uBlock Origin for filterlit and static filters, and uMatrix for the rest. You can also combine uMatrix, uBlock Origin and Scriptsafe.
Then use chrome://flags flags, to display and configure all hidden chromium functions.
I believe you can accomplish most or all of this with Nano Adblocker or uBlockOrigin used in Advanced User Medium Mode and by making use of its unified Logger. uMatrix probably can do more but it is not as easy to use IMO. Please correct me if I am wrong.
Of course, anyway, today we can do a lot of things with all the extensions available.
uBlock O is different from uMatrix. They have some common functions but basically they are very different with advantages and lack for both and are not made for the same use. That’s why combining them is quite possible and make them very powerfull.
To understand uMatrix, we have to think in terms of tabs, while uBlock O only uses one for all settings (local/global). From there, uMatrix is just as easy to use as uBlock O.