The issue is related with the site search feature at brave://settings/searchEngines.
I set the lowercase letter “w” for Wiki. It worked over years until recent times.
Now, nothing happens when I type “w” (plus spacebar) in the address bar.
However it does work in Private and Tor modes.
I disabled all my extensions in Normal mode but “w” does not still work.
My other shortcuts still work whatever the mode. For instance, letter “c” works normally.
When I list all my site shortcuts in brave://settings/searchEngines , the “w” shortcut is disappeared.
If I decide to add the “w” letter, Brave refuses and says invalid.
Brave 1.80.113 (64 bits)
Chromium: 138.0.7204.49