@OurFreeSociety,
Not super clear on what you’re asking here. To me it seems like using a browser running six different profiles at a time, all with different extensions installed will result in a lot of data “build up”. So just clearing cache may not cut it.
When you clear your cache, are you doing so by going to Settings --> History --> Clear browsing data? if so do you see (before you clear the data), how much cache data the browser is about to delete (example image below)? How much is reported (note that I have set my time range to All time in the example)?